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Research Article Free access | 10.1172/JCI108389

The effect of hepatectomy on the synthesis of 25-hydroxyvitamin D3.

E B Olson Jr, J C Knutson, M H Bhattacharyya, and H F DeLuca

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Published May 1, 1976 - More info

Published in Volume 57, Issue 5 on May 1, 1976
J Clin Invest. 1976;57(5):1213–1220. https://doi.org/10.1172/JCI108389.
© 1976 The American Society for Clinical Investigation
Published May 1, 1976 - Version history
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Abstract

The metabolism of [3H]vitamin D3 in hepatectomized vitamin D-deficient rats has been studied. Hepatectomy drastically disrupts vitamin D3 metabolism as revealed by prolonged high levels of [3H] vitamin D3 in the plasma compartment even 12 h after dose in contrast to sham-operated controls. Some conversion of [3H] vitamin D3 to [3H]25-hydroxyvitamin D3 was detected in hepatectomized rats, but the amount was small in spite of the high circulating levels of [3H]vitamin D3. Since the liver initially takes up much of an administered dose in normal animals and the conversion of [3H]vitamin D3 to [3H]25-hydroxyvitamin D3 is small in hepatectomized rats in spite of high circulating [3H]-vitamin D3, it is concluded that the liver plays a major role in the metabolism of vitamin D3 to 25-hydroxy-vitamin D3.

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