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Research Article Free access | 10.1172/JCI108059

Immunoglobulins and complement components in synovial fluid of patients with acute rheumatic fever.

M Svartman, E V Potter, T Poon-King, and D P Earle

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Published July 1, 1975 - More info

Published in Volume 56, Issue 1 on July 1, 1975
J Clin Invest. 1975;56(1):111–117. https://doi.org/10.1172/JCI108059.
© 1975 The American Society for Clinical Investigation
Published July 1, 1975 - Version history
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Abstract

Three components of complement and six other serum proteins were assayed in synovial fluid and serum samples from 25 patients with acute rheumatic fever in Trinidad. The resulting data indicate a relative decrease in both early and late components of complement within the synovial fluids which suggests local activation by immune complexes. Such activation of complement within the joint spaces may play a primary role in development of the inflammatory arthritis of acute rheumatic fever.

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  • Version 1 (July 1, 1975): No description
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