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Research Article Free access | 10.1172/JCI108044

Lymphocytotoxic antibodies in family members of patients with systemic lupus erythematosus.

R J DeHoratius and R P Messner

Find articles by DeHoratius, R. in: PubMed | Google Scholar

Find articles by Messner, R. in: PubMed | Google Scholar

Published June 1, 1975 - More info

Published in Volume 55, Issue 6 on June 1, 1975
J Clin Invest. 1975;55(6):1254–1258. https://doi.org/10.1172/JCI108044.
© 1975 The American Society for Clinical Investigation
Published June 1, 1975 - Version history
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Abstract

57% of sera from 124 relatives of 28 patients with systemic lupus erythematosus (SLE) were found to have antibody directed against lymphocytes. The incidence in 60 members of 16 control families was 3%. Both consanguineous and nonconsanguineous relatives had the antibody in their sera. 68% of close household contacts of the SLE patients showed lymphocytotoxic antibody whereas only 23% of consanguineous relatives who had no household contact with the probands had this antibody. These data suggest that environmental factors may be important in the pathogenesis of SLE.

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