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Research Article Free access | 10.1172/JCI108014

Tyrosinase activity in human skin. Influence of race and age in newborns.

S H Pomerantz and I G Ances

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Published May 1, 1975 - More info

Published in Volume 55, Issue 5 on May 1, 1975
J Clin Invest. 1975;55(5):1127–1131. https://doi.org/10.1172/JCI108014.
© 1975 The American Society for Clinical Investigation
Published May 1, 1975 - Version history
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Abstract

Tyrosinase has been measured in homogenates of foreskins from newborn babies. The tyrosine hydroxylation reaction is dependent upon 3,4-dihydroxyphenylalanine as a cosubstrate, and the Km for tyrosine is 0.15 mM, similar to the value observed for other mammalian tyrosinases. The mean enzyme activity for black babies (n = 169) is about two and one-fourth times that for white babies (n = 82). For white babies there is a significant correlation between age at circumcision and tyrosinase activity. For black babies this correlation becomes significant when four individuals with extremely high tyrosinase activities are omitted from the series.

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