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Research Article Free access | 10.1172/JCI107980

NADPH oxidase deficiency in X-linked chronic granulomatous disease.

D C Hohn and R I Lehrer

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Published April 1, 1975 - More info

Published in Volume 55, Issue 4 on April 1, 1975
J Clin Invest. 1975;55(4):707–713. https://doi.org/10.1172/JCI107980.
© 1975 The American Society for Clinical Investigation
Published April 1, 1975 - Version history
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Abstract

We measured the cyanide-insensitive pyridine nucleotide oxidase activity of fractionated resting and phagocytic neutrophils from 11 normal donors, 1 patient with hereditary deficiency of myeloperoxidase, and 7 patients with X-linked chronic granulomatous disease (CGD). When measured under optimal conditions (at pH 5.5 and in the presence of 0.5 mM Mn++), NADPH oxidase activity increased fourfold with phagocytosis and was six-fold higher than with NADH. Phagocytic neutrophils from patients with CGD were markedly deficient in NADPH oxidase activity.

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