Immunology of the Lower Respiratory Tract II. THE PLAQUE-FORMING RESPONSE OF CANINE LYPHOID TISSUES TO SHEEP ERYTHROCYTES AFTER INTRAPULMONARY OR INTRAVENOUS IMMUNIZATION

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Abstract

Groups of dogs were immunized with sheep erythrocytes administered either directly into the lower respiratory tract (bronchoalveolar spaces) or intravenously. The hemolytic plaque-forming response (Jerne plaque assay) was studied in various canine lymphoid populations (bronchoalveolar cells, hilar lymph nodes, peripheral lymph nodes, and splenic and peripheral blood leukocytes) as a function of time after immunization and as a function of the dose of antigen administered. Serum hemagglutinating antibody titers against sheep erythrocytes were also measured.

Authors

H. B. Kaltreider, L. Kyselka, S. E. Salmon