The effect of adenosine-3′,5′-cyclic monophosphate (cyclic AMP) and N6,O2-dibutyryl adenosine-3′,5′-cyclic monophosphate (dibutyryl cyclic AMP) on renal tubular permeability was studied by microinjection techniques in anesthetized diuretic rats. Radioactive inulin and mannitol were microinjected simultaneously into superficial proximal and distal convolutions and recovery of the isotopes was measured in the urine.
