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Effects of Glucagon on Lipolysis and Ketogenesis in Normal and Diabetic Men
John E. Liljenquist, … , Oscar B. Crofford, Grant W. Liddle
John E. Liljenquist, … , Oscar B. Crofford, Grant W. Liddle
Published January 1, 1974
Citation Information: J Clin Invest. 1974;53(1):190-197. https://doi.org/10.1172/JCI107537.
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Research Article

Effects of Glucagon on Lipolysis and Ketogenesis in Normal and Diabetic Men

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Abstract

The effect of glucagon (50 ng/kg/min) on arterial glycerol concentration and net splanchnic production of total ketones and glucose was studied after an overnight fast in four normal and five insulin-dependent diabetic men. Brachial artery and hepatic vein catheters were inserted and splanchnic blood flow determined using indocyanine green. The glucagon infusion resulted in a mean circulating plasma level of 4,420 pg/ml.

Authors

John E. Liljenquist, James D. Bomboy, Stephen B. Lewis, Bruce C. Sinclair-Smith, Philip W. Felts, William W. Lacy, Oscar B. Crofford, Grant W. Liddle

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