T and B Lymphocytes in Peripheral Blood and Tissue Lesions in Sjögren's Syndrome

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Abstract

Lymphocyte heterogeneity was studied in peripheral blood and salivary gland lesions in 24 patients with Sjögren's syndrome. Peripheral blood B cells, measured by immunofluorescence with specific antiserum to immunoglobulins or by rosette assay with complementcoated erythrocytes, were increased in most patients. Peripheral blood T cells, measured by immunofluorescence with rabbit antiserum to human thymocytes or by rosette assay with sheep erythrocytes, were reduced in eight patients. Three had associated rheumatoid arthritis, two had a generalized lymphoproliferative disorder, and one each had scleroderma, systemic lupus erythematosus, and neuropathy.

Authors

Norman Talal, Robert A. Sylvester, Troy E. Daniels, John S. Greenspan, Ralph C. Williams Jr.