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Research Article Free access | 10.1172/JCI107536

T and B Lymphocytes in Peripheral Blood and Tissue Lesions in Sjögren's Syndrome

Norman Talal, Robert A. Sylvester, Troy E. Daniels, John S. Greenspan, and Ralph C. Williams Jr.

Clinical Immunology Section, Veterans Administration Hospital, University of California, San Francisco, California 94121

Department of Medicine, University of California, San Francisco, California 94121

Department of Oral Biology, University of California, San Francisco, California 94121

Arthritis Unit, Department of Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico 87106

Find articles by Talal, N. in: PubMed | Google Scholar

Clinical Immunology Section, Veterans Administration Hospital, University of California, San Francisco, California 94121

Department of Medicine, University of California, San Francisco, California 94121

Department of Oral Biology, University of California, San Francisco, California 94121

Arthritis Unit, Department of Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico 87106

Find articles by Sylvester, R. in: PubMed | Google Scholar

Clinical Immunology Section, Veterans Administration Hospital, University of California, San Francisco, California 94121

Department of Medicine, University of California, San Francisco, California 94121

Department of Oral Biology, University of California, San Francisco, California 94121

Arthritis Unit, Department of Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico 87106

Find articles by Daniels, T. in: PubMed | Google Scholar

Clinical Immunology Section, Veterans Administration Hospital, University of California, San Francisco, California 94121

Department of Medicine, University of California, San Francisco, California 94121

Department of Oral Biology, University of California, San Francisco, California 94121

Arthritis Unit, Department of Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico 87106

Find articles by Greenspan, J. in: PubMed | Google Scholar

Clinical Immunology Section, Veterans Administration Hospital, University of California, San Francisco, California 94121

Department of Medicine, University of California, San Francisco, California 94121

Department of Oral Biology, University of California, San Francisco, California 94121

Arthritis Unit, Department of Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico 87106

Find articles by Williams, R. in: PubMed | Google Scholar

Published January 1, 1974 - More info

Published in Volume 53, Issue 1 on January 1, 1974
J Clin Invest. 1974;53(1):180–189. https://doi.org/10.1172/JCI107536.
© 1974 The American Society for Clinical Investigation
Published January 1, 1974 - Version history
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Abstract

Lymphocyte heterogeneity was studied in peripheral blood and salivary gland lesions in 24 patients with Sjögren's syndrome. Peripheral blood B cells, measured by immunofluorescence with specific antiserum to immunoglobulins or by rosette assay with complementcoated erythrocytes, were increased in most patients. Peripheral blood T cells, measured by immunofluorescence with rabbit antiserum to human thymocytes or by rosette assay with sheep erythrocytes, were reduced in eight patients. Three had associated rheumatoid arthritis, two had a generalized lymphoproliferative disorder, and one each had scleroderma, systemic lupus erythematosus, and neuropathy.

The salivary gland lymphocytic infiltrates present in labial biopsy specimens were compared in 10 patients using an indirect immunofluorescent method with anti-human T cell serum and a quantitative focus-scoring method. In general, there was a correlation between the number of T cells and the extent of the infiltrate. Striking accumulations of T cells were present in some patients, but clusters of presumed B cells were also seen. These results indicate an increase in peripheral blood B cells in most patients, a decrease in T cells in some, and a mixed T and B cell infiltrate in the salivary gland lesions.

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