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Usage Information

Effects of Cyanate and 2,3-Diphosphoglycerate on Sickling RELATIONSHIP TO OXYGENATION
Michael Jensen, H. Franklin Bunn, George Halikas, Yuet Wai Kan, David G. Nathan
Michael Jensen, H. Franklin Bunn, George Halikas, Yuet Wai Kan, David G. Nathan
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Research Article

Effects of Cyanate and 2,3-Diphosphoglycerate on Sickling RELATIONSHIP TO OXYGENATION

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Abstract

Cyanate and 2,3-diphosphoglycerate (2,3-DPG) both influence the oxygen affinity of hemoglobin. The studies presented here concern the effects of these compounds on the sickling phenomenon. The inhibitory effect of cyanate on sickling is largely due to the fact that it increases the percentage of oxyhemoglobin S at a given oxygen tension. In addition, cyanate inhibits sickling by a mechanism that is independent of oxygenation. In this paper, we have demonstrated that the viscosity of carbamylated sickle blood was lower than that of non-carbamylated controls at the same oxygen saturation. Furthermore, carbamylation resulted in an increase in the minimum concentration of deoxy-sickle hemoglobin required for gelation.

Authors

Michael Jensen, H. Franklin Bunn, George Halikas, Yuet Wai Kan, David G. Nathan

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Usage data is cumulative from July 2025 through July 2026.

Usage JCI PMC
Text version 227 29
PDF 111 11
Scanned page 339 2
Citation downloads 142 0
Totals 819 42
Total Views 861
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

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