Triiodothyronine and Thyroxine in the Serum and Thyroid Glands of Iodine-Deficient Rats

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Abstract

Triiodothyronine (T3) and thyroxine (T4) were measured by immunoassay in the serum and thyroid hydrolysates of control (group A), mildly iodine-deficient (group B), and severely iodine-deficient rats (group C). These results were correlated with changes in thyroidal weight, 131I uptake and 127I content as well as with the distribution of 131I in Pronase digests of the thyroid. There was a progressive increase in thyroid weight and 131I uptake at 24 h with decrease in iodine intake. The 127I content of the thyroids of the group B animals was 44% and that of the group C animals 2% of that in group A. The mean labeled monoiodotyrosine/diiodotyrosine (MIT/DIT) and T3/T4 ratios in group A were 0.42±0.07 (SD) and 0.12±0.01, 0.59±0.06 and 0.11±0.03 in group B, and 2.0±0.3 and 1.8±0.9 in the group thyroid digests.

Authors

G. M. Abrams, P. R. Larsen