Contributions of Loss of Lung Recoil and of Enhanced Airways Collapsibility to the Airflow Obstruction of Chronic Bronchitis and Emphysema

D. G. Leaver; A. E. Tattersfield; N. B. Pride

doi:10.1172/JCI107396

Contributions of Loss of Lung Recoil and of Enhanced Airways Collapsibility to the Airflow Obstruction of Chronic Bronchitis and Emphysema

D. G. Leaver, A. E. Tattersfield, and N. B. Pride

Published September 1, 1973 - More info

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Abstract

We investigated the contributions of intrinsic disease of the airways, loss of lung recoil and enhanced airway collapsibility to the airflow obstruction of 17 patients with chronic bronchitis and emphysema. Airways conductance at low flow (G_aw), maximum expiratory flow (V̇_{E, MAX}) and static lung recoil pressure [P_st (l)] were measured at different lung volumes, and conductance-static recoil pressure and maximum flow-static recoil pressure curves constructed. Low values of ΔG_aw/ΔP_st (l) and ΔV̇_E, max/ΔP_st (l) were attributed to intrinsic airways disease. Airway collapsibility was assessed by comparing G_aw with upstream conductance on forced expiration and by the intercept of the maximum flow-static recoil curve on the static recoil pressure axis (P_tm′).

All patients had reduced G_aw at all volumes but in seven ΔG_aw/ΔP_st (l) was normal. On forced expiration, maximum flow in all patients was reduced more than could be accounted for by loss of lung recoil. ΔV̇_{E, MAX}/ΔP_st (l) was reduced in the patients in whom ΔG_aw/P_st (l) was low. In contrast ΔV̇_{E, MAX}/ΔP_st (l) was normal in three and only slightly reduced in another three of the seven patients with normal ΔG_aw/ΔP_st (l). In these patients G_aw greatly exceeded upstream conductance and P_tm′ was increased.

We conclude that loss of lung recoil could account for the reduction in resting airways dimensions in 7 of the 17 patients. Enhanced airway collapsibility commonly contributed to reduction in maximum flow. In three patients the airflow obstruction could be entirely accounted for by loss of lung recoil and enhanced airway collapsibility.