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Research Article Free access | 10.1172/JCI107351
Department of Pathology, University Hospitals, University of Minnesota, Minneapolis, Minnesota 55455
Department of Pediatrics, University Hospitals, University of Minnesota, Minneapolis, Minnesota 55455
Find articles by Day, N. in: JCI | PubMed | Google Scholar
Department of Pathology, University Hospitals, University of Minnesota, Minneapolis, Minnesota 55455
Department of Pediatrics, University Hospitals, University of Minnesota, Minneapolis, Minnesota 55455
Find articles by Geiger, H. in: JCI | PubMed | Google Scholar
Department of Pathology, University Hospitals, University of Minnesota, Minneapolis, Minnesota 55455
Department of Pediatrics, University Hospitals, University of Minnesota, Minneapolis, Minnesota 55455
Find articles by McLean, R. in: JCI | PubMed | Google Scholar
Department of Pathology, University Hospitals, University of Minnesota, Minneapolis, Minnesota 55455
Department of Pediatrics, University Hospitals, University of Minnesota, Minneapolis, Minnesota 55455
Find articles by Resnick, J. in: JCI | PubMed | Google Scholar
Department of Pathology, University Hospitals, University of Minnesota, Minneapolis, Minnesota 55455
Department of Pediatrics, University Hospitals, University of Minnesota, Minneapolis, Minnesota 55455
Find articles by Michael, A. in: JCI | PubMed | Google Scholar
Department of Pathology, University Hospitals, University of Minnesota, Minneapolis, Minnesota 55455
Department of Pediatrics, University Hospitals, University of Minnesota, Minneapolis, Minnesota 55455
Find articles by Good, R. in: JCI | PubMed | Google Scholar
Published July 1, 1973 - More info
The study of the activation of C3, C5, and C7 associated with the conversion of C3 in the serum of a 9-yr old girl after incubation at 0°C for 6-8 h without utilization of C1, C4, and C2 is described. The patient has upper respiratory infections associated with recurrent gross hematuria, focal glomerulonephritis, and transient renal insufficiency. Histological lesions demonstrated the presence of B1c globulin IgA and properdin in the glomeruli. The activation of complement (C) in the cold requires the patient's IgA. Removal of IgA from the serum by immunoadsorption prevents activation and conversion of C3. Bactericidal and phagocytic activity is also impaired after incubation. C3 proactivator (C3PA) level is reduced before and after incubation. Properdin level drops after incubation. These findings suggest that the activation of C3 which is demonstrable in vitro may be a continuous process in vivo.
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