Identification of Inorganic Pyrophosphate in Human Platelets and Its Release on Stimulation with Thrombin

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Abstract

Serum inorganic pyrophosphate (PPi) levels were consistently two- to threefold higher than plasma PPi prepared from the same blood. PPi was found in platelets in amounts ranging from 1.4 to 3 nmol/108 cells, using three different techniques for quantification. These levels are approximately 800 times higher than the mean PPi concentration in normal plasma and approximate the levels of ADP found in platelets by other workers.

Authors

Donald C. Silcox, Sergio Jacobelli, Daniel J. McCarty