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Concise Publication Free access | 10.1172/JCI107298

Heterogeneity of 5′-Nucleotidase Activity in Lymphocytes in Chronic Lymphocytic Leukemia

John Lopes, Dorothea Zucker-Franklin, and Robert Silber

1Department of Medicine, New York University Medical Center, New York 10016

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1Department of Medicine, New York University Medical Center, New York 10016

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1Department of Medicine, New York University Medical Center, New York 10016

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Published May 1, 1973 - More info

Published in Volume 52, Issue 5 on May 1, 1973
J Clin Invest. 1973;52(5):1297–1300. https://doi.org/10.1172/JCI107298.
© 1973 The American Society for Clinical Investigation
Published May 1, 1973 - Version history
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Abstract

The specific activity of 5′-nucleotidase was determined in lymphocyte plasma membranes from 14 normal subjects and 10 patients with chronic lymphocytic leukemia (CLL). Whereas the enzyme was present in the preparation from normal lymphocytes, in 7 out of 10 CLL patients the membranes had markedly decreased or no detectable 5′-nucleotidase activity. The lack of this activity from the lymphocytes of most patients with CLL constitutes an alteration in a plasma membrane enzyme from the normal cell. The presence of the enzyme in the lymphocytes of some patients with CLL and its decrease in others provide further evidence for biochemical heterogeneity among patients with this disorder.

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