Specific Biologic Effects of Intestinal Glucagon-Like Materials

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Abstract

It has been demonstrated that gastrointestinal extracts contain substances which react immunologically with antibodies prepared to pancreatic glucagon. These extracts have been termed intestinal GLI for glucagon-like immunoreactivity, or enteroglucagon. To determine whether GLI has specific biological effects, studies were designed using the criterion of effect with antiglucagon antibodies. These antibodies did not cross-react with either secretin or pancreozymin.

Authors

Raul A. Gutman, Gloria Fink, Nancy Voyles, Helena Selawry, Juan C. Penhos, Albert Lepp, Lillian Recant