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Estrogen Receptors in Human Breast Cancer
William L. McGuire
William L. McGuire
Published January 1, 1973
Citation Information: J Clin Invest. 1973;52(1):73-77. https://doi.org/10.1172/JCI107175.
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Research Article

Estrogen Receptors in Human Breast Cancer

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Abstract

Specific quantitative techniques have been used to measure the cytoplasmic estradiol-binding protein (EBP) in human mammary carcinoma tissue specimens. Sucrose gradient centrifugation reveals EBP to sediment at 8S and 4S. Variable quantities of non-specific estradiol binding occurs in the 4S region of the sucrose gradient necessitating controls to insure specificity of the estradiol protein interaction.

Authors

William L. McGuire

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