Studies on the Response of Patients with Classic Hemophilia to Transfusion with Concentrates of Antihemophilic Factor: <i>A DIFFERENCE IN THE HALF-LIFE OF ANTIHEMOPHILIC FACTOR AS MEASURED BY PROCOAGULANT AND IMMUNOLOGIC TECHNIQUES</i>

Bruce Bennett; Oscar D. Ratnoff

doi:10.1172/JCI107076

Studies on the Response of Patients with Classic Hemophilia to Transfusion with Concentrates of Antihemophilic Factor: A DIFFERENCE IN THE HALF-LIFE OF ANTIHEMOPHILIC FACTOR AS MEASURED BY PROCOAGULANT AND IMMUNOLOGIC TECHNIQUES

Published October 1, 1972 - More info

View PDF

Abstract

Antihemophilic factor (AHF, factor VIII) levels were measured by a standard coagulation method and by an immunologic technique before and after infusion of AHF concentrates into patients with classic hemophilia. After infusion of AHF concentrates, the half-life of the AHF procoagulant (i.e., clot-promoting) activity varied from 12 to 14 hr, whereas that of the antigen ranged from 24 to 40 hr. The half-life of the antigen was similar in patients with and without circulating anticoagulants to AHF. The data are compatible with the suggestion that the antigen may be carried on a precursor molecule which the patient with hemophilia produces but cannot convert to the functional clot-promoting agent. Other explanations of the observations are, however, recognized.

Studies on the Response of Patients with Classic Hemophilia to Transfusion with Concentrates of Antihemophilic Factor: A DIFFERENCE IN THE HALF-LIFE OF ANTIHEMOPHILIC FACTOR AS MEASURED BY PROCOAGULANT AND IMMUNOLOGIC TECHNIQUES

Bruce Bennett and Oscar D. Ratnoff

Article tools

Metrics

Go to

Studies on the Response of Patients with Classic Hemophilia to Transfusion with Concentrates of Antihemophilic Factor: A DIFFERENCE IN THE HALF-LIFE OF ANTIHEMOPHILIC FACTOR AS MEASURED BY PROCOAGULANT AND IMMUNOLOGIC TECHNIQUES

Bruce Bennett and Oscar D. Ratnoff

Article tools

Metrics

Go to

Sign up for email alerts