Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Pancreatic Cancer (Jul 2025)
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
Top
  • View PDF
  • Download citation information
  • Send a comment
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal
  • Top
  • Abstract
  • Version history
  • Article usage
  • Citations to this article

Advertisement

Research Article Free access | 10.1172/JCI106981

Tyrosine hydroxylase in human adrenal and pheochromocytoma: localization, kinetics, and catecholamine inhibition

J. C. Waymire, N. Weiner, F. H. Schneider, M. Goldstein, and L. S. Freedman

Department of Pharmacology, University of Colorado School of Medicine, Denver, Colorado 80220

Department of Psychiatry, New York University Medical Center, New York 10016

Find articles by Waymire, J. in: PubMed | Google Scholar

Department of Pharmacology, University of Colorado School of Medicine, Denver, Colorado 80220

Department of Psychiatry, New York University Medical Center, New York 10016

Find articles by Weiner, N. in: PubMed | Google Scholar

Department of Pharmacology, University of Colorado School of Medicine, Denver, Colorado 80220

Department of Psychiatry, New York University Medical Center, New York 10016

Find articles by Schneider, F. in: PubMed | Google Scholar

Department of Pharmacology, University of Colorado School of Medicine, Denver, Colorado 80220

Department of Psychiatry, New York University Medical Center, New York 10016

Find articles by Goldstein, M. in: PubMed | Google Scholar

Department of Pharmacology, University of Colorado School of Medicine, Denver, Colorado 80220

Department of Psychiatry, New York University Medical Center, New York 10016

Find articles by Freedman, L. in: PubMed | Google Scholar

Published July 1, 1972 - More info

Published in Volume 51, Issue 7 on July 1, 1972
J Clin Invest. 1972;51(7):1798–1804. https://doi.org/10.1172/JCI106981.
© 1972 The American Society for Clinical Investigation
Published July 1, 1972 - Version history
View PDF
Abstract

The properties of partially purified tyrosine hydroxylase from six pheochromocytomas were compared with partially purified normal human and bovine adrenal medulla enzyme. Substrate and inhibition kinetics, cofactor requirements, and intracellular localization of the enzyme from normal and tumor chromaffin tissue of humans were similar, as was the amount of enzyme activity per gram of tissue. Contrary to previous reports, the sensitivity to catecholamine inhibition of the pheochromocytoma enzyme from the six tumors studied was similar to that of both human and bovine adrenal medulla tyrosine hydroxylase. These results suggest that the excessive synthesis and secretion of catecholamines in some pheochromocytomas is not the result of a reduced sensitivity of tyrosine hydroxylase to catecholamine inhibition.

Browse pages

Click on an image below to see the page. View PDF of the complete article

icon of scanned page 1798
page 1798
icon of scanned page 1799
page 1799
icon of scanned page 1800
page 1800
icon of scanned page 1801
page 1801
icon of scanned page 1802
page 1802
icon of scanned page 1803
page 1803
icon of scanned page 1804
page 1804
Version history
  • Version 1 (July 1, 1972): No description

Article tools

  • View PDF
  • Download citation information
  • Send a comment
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal

Metrics

  • Article usage
  • Citations to this article

Go to

  • Top
  • Abstract
  • Version history
Advertisement
Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts