Platelet Interaction with Polymerizing Fibrin

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Abstract

Interaction of washed pig, rabbit, or human platelets with fibrinogen was studied during its transition to fibrin using photometric, isotopic, and electron microscopic techniques. Untreated fibrinogen and fully polymerized fibrin had no detectable effect on platelets. Fibrinogen, incubated with low concentrations of reptilase or thrombin, formed intermediate products which readily became associated with platelets and caused their aggregation. Neutralization of the thrombin did not prevent this interaction. In the absence of fibrinogen, reptilase did not affect platelets.

Authors

Stefan Niewiarowski, Erwin Rogoeczi, Gwendolyn J. Steward, Andrew F. Senyi, J. Fraser Mustard