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Concise Publication Free access | 10.1172/JCI106693

Stimulation of granulocytopoiesis by a diffusible factor in vivo

G. Rothstein, E. H. Hügl, C. R. Bishop, J. W. Athens, and H. E. Ashenbrucker

Department of Internal Medicine, the Veterans Administration Hospital, Salt Lake City, Utah 84112

University of Utah College of Medicine, Salt Lake City, Utah 84112

Find articles by Rothstein, G. in: JCI | PubMed | Google Scholar

Department of Internal Medicine, the Veterans Administration Hospital, Salt Lake City, Utah 84112

University of Utah College of Medicine, Salt Lake City, Utah 84112

Find articles by Hügl, E. in: JCI | PubMed | Google Scholar

Department of Internal Medicine, the Veterans Administration Hospital, Salt Lake City, Utah 84112

University of Utah College of Medicine, Salt Lake City, Utah 84112

Find articles by Bishop, C. in: JCI | PubMed | Google Scholar

Department of Internal Medicine, the Veterans Administration Hospital, Salt Lake City, Utah 84112

University of Utah College of Medicine, Salt Lake City, Utah 84112

Find articles by Athens, J. in: JCI | PubMed | Google Scholar

Department of Internal Medicine, the Veterans Administration Hospital, Salt Lake City, Utah 84112

University of Utah College of Medicine, Salt Lake City, Utah 84112

Find articles by Ashenbrucker, H. in: JCI | PubMed | Google Scholar

Published September 1, 1971 - More info

Published in Volume 50, Issue 9 on September 1, 1971
J Clin Invest. 1971;50(9):2004–2007. https://doi.org/10.1172/JCI106693.
© 1971 The American Society for Clinical Investigation
Published September 1, 1971 - Version history
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Abstract

A millipore diffusion chamber system was used to cultivate mouse marrow in the abdomens of irradiated and unirradiated host mice for 24 hr. When the irradiated hosts were 72, 96, or 120 hr postirradiation, the number of blasts and promyelocytes in the implanted chambers after cultivation was greater than those in the same marrow cultivated in unirradiated hosts. These data indicate that in vivo, there is stimulation of granulocytopoiesis by a diffusible factor or factors.

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