Progeria: a cell culture study on aging

B. Shannon Danes

doi:10.1172/JCI106692

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Concise Publication Free access | 10.1172/JCI106692

Progeria: a cell culture study on aging

B. Shannon Danes

¹Division of Human Genetics, Department of Medicine, Cornell University Medical College, New York 10021

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Published September 1, 1971 - More info

Published in Volume 50, Issue 9 on September 1, 1971
J Clin Invest. 1971;50(9):2000–2003. https://doi.org/10.1172/JCI106692.
© 1971 The American Society for Clinical Investigation

Published September 1, 1971 - Version history

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Abstract

Progeria is an autosomal recessive disorder showing precocious senility. The cultured skin fibroblast from both the homozygous affected individual and the heterozygous parents can be distinguished from normals by decreased cell growth in culture. Mitotic activity, DNA synthesis, and cloning efficiency are markedly reduced.

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