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Usage Information

Amino acid oxidase of leukocytes in relation to H2O2-mediated bacterial killing
Marlene R. Eckstein, Robert L. Baehner, David G. Nathan
Marlene R. Eckstein, Robert L. Baehner, David G. Nathan
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Research Article

Amino acid oxidase of leukocytes in relation to H2O2-mediated bacterial killing

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Abstract

D-Amino acid oxidase and L-amino acid oxidase have been measured in sucrose homogenates of polymorphonuclear leukocytes (PMN) obtained from guinea pigs and humans. Subcellular distribution patterns and studies on latency indicate that these oxidases are soluble enzymes. Their hydrogen peroxide-generating capacity was verified. Chronic granulomatous disease PMN, which lack a respiratory burst and fail to generate H2O2 during phagocytosis and do not kill catalase positive bacteria, had peroxide-generating amino acid oxidase activity equal to that found in PMN homogenates from patients with bacterial infections. The precise metabolic and bactericidal role of amino acid oxidases in PMN remains uncertain.

Authors

Marlene R. Eckstein, Robert L. Baehner, David G. Nathan

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Usage data is cumulative from October 2025 through October 2026.

Usage JCI PMC
Text version 281 10
PDF 132 7
Scanned page 512 2
Citation downloads 227 0
Totals 1,152 19
Total Views 1,171
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

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