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Research Article Free access | 10.1172/JCI106651
Laboratory of Protein Chemistry, Medical College of Georgia, Augusta, Georgia 30902
Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91109
Childrens Hospital of Los Angeles, Los Angeles, California 90054
Department of Pediatrics, University of Southern California School of Medicine, Los Angeles, California 90033
Find articles by Efremov, G. in: PubMed | Google Scholar
Laboratory of Protein Chemistry, Medical College of Georgia, Augusta, Georgia 30902
Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91109
Childrens Hospital of Los Angeles, Los Angeles, California 90054
Department of Pediatrics, University of Southern California School of Medicine, Los Angeles, California 90033
Find articles by Wrightstone, R. in: PubMed | Google Scholar
Laboratory of Protein Chemistry, Medical College of Georgia, Augusta, Georgia 30902
Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91109
Childrens Hospital of Los Angeles, Los Angeles, California 90054
Department of Pediatrics, University of Southern California School of Medicine, Los Angeles, California 90033
Find articles by Huisman, T. in: PubMed | Google Scholar
Laboratory of Protein Chemistry, Medical College of Georgia, Augusta, Georgia 30902
Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91109
Childrens Hospital of Los Angeles, Los Angeles, California 90054
Department of Pediatrics, University of Southern California School of Medicine, Los Angeles, California 90033
Find articles by Schroeder, W. in: PubMed | Google Scholar
Laboratory of Protein Chemistry, Medical College of Georgia, Augusta, Georgia 30902
Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91109
Childrens Hospital of Los Angeles, Los Angeles, California 90054
Department of Pediatrics, University of Southern California School of Medicine, Los Angeles, California 90033
Find articles by Hyman, C. in: PubMed | Google Scholar
Laboratory of Protein Chemistry, Medical College of Georgia, Augusta, Georgia 30902
Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91109
Childrens Hospital of Los Angeles, Los Angeles, California 90054
Department of Pediatrics, University of Southern California School of Medicine, Los Angeles, California 90033
Find articles by Ortega, J. in: PubMed | Google Scholar
Laboratory of Protein Chemistry, Medical College of Georgia, Augusta, Georgia 30902
Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91109
Childrens Hospital of Los Angeles, Los Angeles, California 90054
Department of Pediatrics, University of Southern California School of Medicine, Los Angeles, California 90033
Find articles by Williams, K. in: PubMed | Google Scholar
Published August 1, 1971 - More info
A Chinese family with hemoglobin H in the propositus has been reinvestigated. Although the original propositus is now deceased, a sister has the same hematological manifestations. Her hemoglobin, like that of the deceased sister, contains hemoglobins A, H, and Bart's. In addition, however, two minor components have been detected. These minor components appear to have abnormal α-chains and are also present in the maternal grandmother, the mother, a maternal aunt, and three other siblings but only in about one-tenth the amount. One of the minor components may be the same as Hb-Thai (25). The father has the characteristics of classical α-thalassemia. These results are discussed in relation to current concepts of α-thalassemia as they relate to “silent” and “classical” α-thalassemia and to possible multiple α-chain loci.
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