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Concise Publication Free access | 10.1172/JCI106641

Dose-Response relationship of luteinizing hormone to luteinizing hormone—releasing hormone in man

Abba J. Kastin, Andrew V. Schally, Carlos Gual, A. Rees Midgley Jr., M. Clinton Miller III, and Angela Cabeza

Endocrine and Polypeptide Laboratories, Endocrinology Section of the Medical Service, Veterans Administration Hospital, and Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70140

Instituto Nacional de la Nutricion, Mexico, D.F.

Department of Pathology, University of Michigan, Ann Arbor, Michigan 48104

Department of Biometry, Medical University of South Carolina, Charleston, South Carolina 29401

Find articles by Kastin, A. in: PubMed | Google Scholar

Endocrine and Polypeptide Laboratories, Endocrinology Section of the Medical Service, Veterans Administration Hospital, and Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70140

Instituto Nacional de la Nutricion, Mexico, D.F.

Department of Pathology, University of Michigan, Ann Arbor, Michigan 48104

Department of Biometry, Medical University of South Carolina, Charleston, South Carolina 29401

Find articles by Schally, A. in: PubMed | Google Scholar

Endocrine and Polypeptide Laboratories, Endocrinology Section of the Medical Service, Veterans Administration Hospital, and Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70140

Instituto Nacional de la Nutricion, Mexico, D.F.

Department of Pathology, University of Michigan, Ann Arbor, Michigan 48104

Department of Biometry, Medical University of South Carolina, Charleston, South Carolina 29401

Find articles by Gual, C. in: PubMed | Google Scholar

Endocrine and Polypeptide Laboratories, Endocrinology Section of the Medical Service, Veterans Administration Hospital, and Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70140

Instituto Nacional de la Nutricion, Mexico, D.F.

Department of Pathology, University of Michigan, Ann Arbor, Michigan 48104

Department of Biometry, Medical University of South Carolina, Charleston, South Carolina 29401

Find articles by Midgley, A. in: PubMed | Google Scholar

Endocrine and Polypeptide Laboratories, Endocrinology Section of the Medical Service, Veterans Administration Hospital, and Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70140

Instituto Nacional de la Nutricion, Mexico, D.F.

Department of Pathology, University of Michigan, Ann Arbor, Michigan 48104

Department of Biometry, Medical University of South Carolina, Charleston, South Carolina 29401

Find articles by Miller, M. in: PubMed | Google Scholar

Endocrine and Polypeptide Laboratories, Endocrinology Section of the Medical Service, Veterans Administration Hospital, and Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70140

Instituto Nacional de la Nutricion, Mexico, D.F.

Department of Pathology, University of Michigan, Ann Arbor, Michigan 48104

Department of Biometry, Medical University of South Carolina, Charleston, South Carolina 29401

Find articles by Cabeza, A. in: PubMed | Google Scholar

Published July 1, 1971 - More info

Published in Volume 50, Issue 7 on July 1, 1971
J Clin Invest. 1971;50(7):1551–1553. https://doi.org/10.1172/JCI106641.
© 1971 The American Society for Clinical Investigation
Published July 1, 1971 - Version history
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Abstract

In previous clinical studies with highly purified porcine luteinizing hormone-releasing hormone (LH-RH), administration of the somewhat arbitrarily chosen doses of 700-1500 μg resulted in increased serum levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). The present study determined the minimum effective dose as well as the relationship of the response of serum LH and FSH to the dose of LH-RH administered. Three normal men received i.v. injections of 1.1-810 μg of LH-RH. A dose of 10 μg of LH-RH caused a statistically significant elevation in serum LH. 30 μg of LH-RH significantly increased serum FSH levels. A highly significant linear trend was observed in the log dose-response curve. The results indicate that both LH and FSH release occurs in man with doses of LH-RH much lower than previously used and that a linear log dose-response relationship can be obtained.

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