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Usage Information

NB1, a new neutrophil-specific antigen involved in the pathogenesis of neonatal neutropenia
Parviz Lalezari, Georgette B. Murphy, Fred H. Allen Jr.
Parviz Lalezari, Georgette B. Murphy, Fred H. Allen Jr.
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Research Article

NB1, a new neutrophil-specific antigen involved in the pathogenesis of neonatal neutropenia

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Abstract

A new human antigen is reported which is present only on blood neutrophils. A neutrophil-specific antigen, designated NA1, has previously been identified in two unrelated families, and was shown to be involved in fetomaternal incompatibility and the development of isoimmune neonatal neutropenia in five newborns. In the present paper, a second antigen, designated NB1, is identified in four families with seven affected children. Antibodies that react with this second antigen are shown to produce selective agglutination of neutrophils but not other blood cells. They are neither absorbed by cells prepared from solid tissues nor by non-neutrophilic blood cells.

Authors

Parviz Lalezari, Georgette B. Murphy, Fred H. Allen Jr.

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Usage data is cumulative from July 2025 through July 2026.

Usage JCI PMC
Text version 736 99
PDF 130 14
Scanned page 508 13
Citation downloads 145 0
Totals 1,519 126
Total Views 1,645
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