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Radioimmunoassay of human parathyroid hormone in serum
Claude D. Arnaud, … , Hang S. Tsao, Travis Littledike
Claude D. Arnaud, … , Hang S. Tsao, Travis Littledike
Published January 1, 1971
Citation Information: J Clin Invest. 1971;50(1):21-34. https://doi.org/10.1172/JCI106476.
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Research Article

Radioimmunoassay of human parathyroid hormone in serum

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Abstract

A new radioimmunoassay for human parathyroid hormone (PTH) in serum, which can measure the hormone present in 94% of the normal sera tested, is described. It is based on the ability of human PTH to compete with 131I-labeled bovine PTH for binding to an antiserum directed against porcine PTH. This antiserum distinguishes between human PTH extracted from parathyroid adenomata and that present in hyperparathyroid sera. Evidence is given to suggest that this is due to immunochemical changes in the hormone extracted from adenomata and not to immunochemical heterogeneity of the hormone present in serum.

Authors

Claude D. Arnaud, Hang S. Tsao, Travis Littledike

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