Advertisement

Research Article Free access | 10.1172/JCI106356

Transplacental passage and fetal secretion of aldosterone

Francis Bayard, Isadore G. Ances, Alan J. Tapper, Virginia V. Weldon, Avinoam Kowarski, and Claude J. Migeon

Harriet Lane Service of the Children's Medical and Surgical Center, and the Department of Obstetrics and Gynecology, The Johns Hopkins Hospital and University, Baltimore, Maryland 21205

Department of Obstetrics and Gynecology of the University of Maryland, School of Medicine, Baltimore, Maryland 21201

Find articles by Bayard, F. in: JCI | PubMed | Google Scholar

Harriet Lane Service of the Children's Medical and Surgical Center, and the Department of Obstetrics and Gynecology, The Johns Hopkins Hospital and University, Baltimore, Maryland 21205

Department of Obstetrics and Gynecology of the University of Maryland, School of Medicine, Baltimore, Maryland 21201

Find articles by Ances, I. in: JCI | PubMed | Google Scholar

Harriet Lane Service of the Children's Medical and Surgical Center, and the Department of Obstetrics and Gynecology, The Johns Hopkins Hospital and University, Baltimore, Maryland 21205

Department of Obstetrics and Gynecology of the University of Maryland, School of Medicine, Baltimore, Maryland 21201

Find articles by Tapper, A. in: JCI | PubMed | Google Scholar

Harriet Lane Service of the Children's Medical and Surgical Center, and the Department of Obstetrics and Gynecology, The Johns Hopkins Hospital and University, Baltimore, Maryland 21205

Department of Obstetrics and Gynecology of the University of Maryland, School of Medicine, Baltimore, Maryland 21201

Find articles by Weldon, V. in: JCI | PubMed | Google Scholar

Harriet Lane Service of the Children's Medical and Surgical Center, and the Department of Obstetrics and Gynecology, The Johns Hopkins Hospital and University, Baltimore, Maryland 21205

Department of Obstetrics and Gynecology of the University of Maryland, School of Medicine, Baltimore, Maryland 21201

Find articles by Kowarski, A. in: JCI | PubMed | Google Scholar

Harriet Lane Service of the Children's Medical and Surgical Center, and the Department of Obstetrics and Gynecology, The Johns Hopkins Hospital and University, Baltimore, Maryland 21205

Department of Obstetrics and Gynecology of the University of Maryland, School of Medicine, Baltimore, Maryland 21201

Find articles by Migeon, C. in: JCI | PubMed | Google Scholar

Published July 1, 1970 - More info

Published in Volume 49, Issue 7 on July 1, 1970
J Clin Invest. 1970;49(7):1389–1393. https://doi.org/10.1172/JCI106356.
© 1970 The American Society for Clinical Investigation
Published July 1, 1970 - Version history
View PDF
Abstract

The transplacental passage and the production of aldosterone were studied in late pregnancy during a constant infusion of 1,2-aldosterone-3H to mothers at the time of elective cesarean section.

It was found that, while maternal aldosterone crossed the placenta, there was a significant secretion of aldosterone by the fetus. The aldosterone concentration in fetal plasma was 2-12 times higher than that of the corresponding mothers.

Pregnancy had no effect on the metabolic clearance rate of aldosterone, but it increased the rate of production of this steroid. However, the increments that we observed were smaller than those reported in previous reports. The discrepancy was probably due to differences in body posture, our subjects being supine for at least 10 hr at the time of study.

Browse pages

Click on an image below to see the page. View PDF of the complete article

Version history
  • Version 1 (July 1, 1970): No description
Advertisement
Advertisement