Altered immunoglobulin metabolism in systemic lupus erythematosus and rheumatoid arthritis

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Abstract

IgG and IgM metabolism was evaluated in 10 patients with systemic lupus erythematosus (SLE), 10 patients with rheumatoid arthritis (RA), and in seven normal volunteers. The biological half-lives of purified IgG and IgM, labeled with 131I and 125I, respectively, were determined by serial measurements of radioactivity in the blood and urine with a gamma well counter, and by serial counts of total body radioactivity in a total body counting chamber.

Authors

Joshua Levy, Eugene V. Barnett, Norman S. MacDonald, James R. Klinenberg