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Research Article Free access | 10.1172/JCI106210

Energy substrate metabolism in fresh and stored human platelets

Phin Cohen and Benjamin Wittels

Department of Biochemistry, the State University of Utrecht, The Netherlands

Department of Medicine, Harvard Medical School and the Peter Bent Brigham Hospital, Boston, Massachusetts 02115

Department of Pathology, Duke University Medical School, Durham, North Carolina 27706

Find articles by Cohen, P. in: PubMed | Google Scholar

Department of Biochemistry, the State University of Utrecht, The Netherlands

Department of Medicine, Harvard Medical School and the Peter Bent Brigham Hospital, Boston, Massachusetts 02115

Department of Pathology, Duke University Medical School, Durham, North Carolina 27706

Find articles by Wittels, B. in: PubMed | Google Scholar

Published January 1, 1970 - More info

Published in Volume 49, Issue 1 on January 1, 1970
J Clin Invest. 1970;49(1):119–127. https://doi.org/10.1172/JCI106210.
© 1970 The American Society for Clinical Investigation
Published January 1, 1970 - Version history
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Abstract

The latent capacity of human platelets for oxidizing several important energy-yielding substrates has been revealed by hypoosmolaric incubation conditions.

The data show that the human platelet has a considerable capacity to oxidize both glucose and long-chain fatty acids. Long-chain fatty acids appear to rank favorably with glucose as a potential energy substrate. In a number of mammalian tissues, (—)-carnitine serves to regulate the rate at which long-chain fatty acids are oxidized. Evidence was obtained which suggests that (—)-carnitine functions in a similar role in the platelet.

After storage of human platelets at 4°C for 24 hr, the oxidative capacity for glucose was reduced by approximately 25% and for long-chain fatty acids by almost 50%. Investigation of the component parts of the metabolic pathways indicated that a marked decrease in the capacity of the Krebs cycle could be responsible for the decrement in energy substrate oxidation.

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