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Research Article Free access | 10.1172/JCI106175

Tocopherol transport in the rat erythrocyte

R. Silber, R. Winter, and H. J. Kayden

1Department of Medicine, New York University School of Medicine, New York 10016

Find articles by Silber, R. in: JCI | PubMed | Google Scholar

1Department of Medicine, New York University School of Medicine, New York 10016

Find articles by Winter, R. in: JCI | PubMed | Google Scholar

1Department of Medicine, New York University School of Medicine, New York 10016

Find articles by Kayden, H. in: JCI | PubMed | Google Scholar

Published November 1, 1969 - More info

Published in Volume 48, Issue 11 on November 1, 1969
J Clin Invest. 1969;48(11):2089–2095. https://doi.org/10.1172/JCI106175.
© 1969 The American Society for Clinical Investigation
Published November 1, 1969 - Version history
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Abstract

The transport of vitamin E (α-tocopherol) has been studied in the rat erythrocyte in vivo and in vitro. Uptake and efflux are independent of energy, but sensitive to temperature. Tocopherol is localized to the cell membrane. Rapid exchange takes place between erythrocytes and serum with an hourly fractional tocopherol efflux of 26%. The vitamin is transferred from the erythrocyte to the low density lipoproteins. These experiments indicate that tocopherol, like cholesterol, is a constituent of the erythrocyte membrane which is in dynamic equilibrium with the corresponding plasma compound.

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