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Usage Information

Hemoglobin NYU, a delta chain variant, α2δ212Lys
Helen M. Ranney, … , Bracha Ramot, Thomas B. Bradley Jr.
Helen M. Ranney, … , Bracha Ramot, Thomas B. Bradley Jr.
Published November 1, 1969
Citation Information: J Clin Invest. 1969;48(11):2057-2062. https://doi.org/10.1172/JCI106171.
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Research Article

Hemoglobin NYU, a delta chain variant, α2δ212Lys

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Abstract

A minor hemoglobin (Hb) component with the electrophoretic properties of the δ-chain variant Hb A2′ was encountered in two unrelated families of Russian-Jewish ancestry. This minor component, designated Hb NYU, was shown to result from the substitution of lysine for asparagine at δ12. We have confirmed studies of others that hemoglobin A2′ isolated from the hemoglobin of some African subjects, results from the replacement of the normal glycine at δ16 by arginine. Thus for interpretations of the incidence of δ-chain variants in different populations, electrophoretic data are not sufficient.

Authors

Helen M. Ranney, Alan S. Jacobs, Bracha Ramot, Thomas B. Bradley Jr.

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Usage data is cumulative from May 2024 through May 2025.

Usage JCI PMC
Text version 105 17
PDF 57 14
Scanned page 228 2
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