Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Alerts
  • Advertising/recruitment
  • Subscribe
  • Contact
  • Current Issue
  • Past Issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Author's Takes
  • Reviews
    • View all reviews ...
    • 100th Anniversary of Insulin's Discovery (Jan 2021)
    • Hypoxia-inducible factors in disease pathophysiology and therapeutics (Oct 2020)
    • Latency in Infectious Disease (Jul 2020)
    • Immunotherapy in Hematological Cancers (Apr 2020)
    • Big Data's Future in Medicine (Feb 2020)
    • Mechanisms Underlying the Metabolic Syndrome (Oct 2019)
    • Reparative Immunology (Jul 2019)
    • View all review series ...
  • Viewpoint
  • Collections
    • Recently published
    • In-Press Preview
    • Commentaries
    • Concise Communication
    • Editorials
    • Viewpoint
    • Top read articles
  • Clinical Medicine
  • JCI This Month
    • Current issue
    • Past issues

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Author's Takes
  • Recently published
  • In-Press Preview
  • Commentaries
  • Concise Communication
  • Editorials
  • Viewpoint
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Alerts
  • Advertising/recruitment
  • Subscribe
  • Contact
Top
  • View PDF
  • Download citation information
  • Send a letter
  • Share this article
  • Terms of use
  • Standard abbreviations
  • Need Help? E-mail the JCI
  • Top
  • Abstract
  • Version history
  • Article usage
  • Citations to this article

Advertisement

Research Article Free access | 10.1172/JCI106171

Hemoglobin NYU, a delta chain variant, α2δ212Lys

Helen M. Ranney, Alan S. Jacobs, Bracha Ramot, and Thomas B. Bradley Jr.

Department of Medicine and Heredity Clinic, Albert Einstein College of Medicine, Bronx, New York 10461

Department of Medicine, Tel Hashomer Hospital, Israel

Find articles by Ranney, H. in: JCI | PubMed | Google Scholar

Department of Medicine and Heredity Clinic, Albert Einstein College of Medicine, Bronx, New York 10461

Department of Medicine, Tel Hashomer Hospital, Israel

Find articles by Jacobs, A. in: JCI | PubMed | Google Scholar

Department of Medicine and Heredity Clinic, Albert Einstein College of Medicine, Bronx, New York 10461

Department of Medicine, Tel Hashomer Hospital, Israel

Find articles by Ramot, B. in: JCI | PubMed | Google Scholar

Department of Medicine and Heredity Clinic, Albert Einstein College of Medicine, Bronx, New York 10461

Department of Medicine, Tel Hashomer Hospital, Israel

Find articles by Bradley, T. in: JCI | PubMed | Google Scholar

Published November 1, 1969 - More info

Published in Volume 48, Issue 11 on November 1, 1969
J Clin Invest. 1969;48(11):2057–2062. https://doi.org/10.1172/JCI106171.
© 1969 The American Society for Clinical Investigation
Published November 1, 1969 - Version history
View PDF
Abstract

A minor hemoglobin (Hb) component with the electrophoretic properties of the δ-chain variant Hb A2′ was encountered in two unrelated families of Russian-Jewish ancestry. This minor component, designated Hb NYU, was shown to result from the substitution of lysine for asparagine at δ12. We have confirmed studies of others that hemoglobin A2′ isolated from the hemoglobin of some African subjects, results from the replacement of the normal glycine at δ16 by arginine. Thus for interpretations of the incidence of δ-chain variants in different populations, electrophoretic data are not sufficient.

In members of one of the families in the present study, the visual estimations of normal Hb A2 and of Hb NYU on starch-gel electrophoretic patterns suggested the presence of δ-thalassemia. In hemolysates of one of the heterozygotes for Hb NYU, hemoglobin A2 was not demonstrable with starch-gel electrophoretic methods but was readily recovered by column chromatography in approximately the amounts expected for δ-chain heterozygotes.

Images.

Browse pages

Click on an image below to see the page. View PDF of the complete article

icon of scanned page 2057
page 2057
icon of scanned page 2058
page 2058
icon of scanned page 2059
page 2059
icon of scanned page 2060
page 2060
icon of scanned page 2061
page 2061
icon of scanned page 2062
page 2062
Version history
  • Version 1 (November 1, 1969): No description

Article tools

  • View PDF
  • Download citation information
  • Send a letter
  • Share this article
  • Terms of use
  • Standard abbreviations
  • Need Help? E-mail the JCI

Metrics

  • Article usage
  • Citations to this article

Go to

  • Top
  • Abstract
  • Version history
Advertisement
Advertisement
Follow JCI:
Copyright © 2021 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts