Hemoglobin NYU, a delta chain variant, α2δ212Lys

Helen M. Ranney; Alan S. Jacobs; Bracha Ramot; Thomas B. Bradley

doi:10.1172/JCI106171

^{Department of Medicine and Heredity Clinic, Albert Einstein College of Medicine, Bronx, New York 10461}

^{Department of Medicine, Tel Hashomer Hospital, Israel}

Find articles by Ranney, H. in: JCI | PubMed | Google Scholar

^{Department of Medicine and Heredity Clinic, Albert Einstein College of Medicine, Bronx, New York 10461}

^{Department of Medicine, Tel Hashomer Hospital, Israel}

Find articles by Jacobs, A. in: JCI | PubMed | Google Scholar

^{Department of Medicine and Heredity Clinic, Albert Einstein College of Medicine, Bronx, New York 10461}

^{Department of Medicine, Tel Hashomer Hospital, Israel}

Find articles by Ramot, B. in: JCI | PubMed | Google Scholar

^{Department of Medicine and Heredity Clinic, Albert Einstein College of Medicine, Bronx, New York 10461}

^{Department of Medicine, Tel Hashomer Hospital, Israel}

Find articles by Bradley, T. in: JCI | PubMed | Google Scholar

Published in Volume 48, Issue 11 on November 1, 1969
J Clin Invest. 1969;48(11):2057–2062. https://doi.org/10.1172/JCI106171.
© 1969 The American Society for Clinical Investigation

Published November 1, 1969 - Version history

A minor hemoglobin (Hb) component with the electrophoretic properties of the δ-chain variant Hb A_2′ was encountered in two unrelated families of Russian-Jewish ancestry. This minor component, designated Hb NYU, was shown to result from the substitution of lysine for asparagine at δ¹². We have confirmed studies of others that hemoglobin A_2′ isolated from the hemoglobin of some African subjects, results from the replacement of the normal glycine at δ¹⁶ by arginine. Thus for interpretations of the incidence of δ-chain variants in different populations, electrophoretic data are not sufficient.

In members of one of the families in the present study, the visual estimations of normal Hb A₂ and of Hb NYU on starch-gel electrophoretic patterns suggested the presence of δ-thalassemia. In hemolysates of one of the heterozygotes for Hb NYU, hemoglobin A₂ was not demonstrable with starch-gel electrophoretic methods but was readily recovered by column chromatography in approximately the amounts expected for δ-chain heterozygotes.

Images.