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Research Article Free access | 10.1172/JCI106152

Effect of decreased O2 supply to tissue on the lactate:pyruvate ratio in blood

William A. Neill, Peter E. Jensen, Gerald B. Rich, and John D. Werschkul

1Department of Medicine, University of Oregon Medical School, Portland, Oregon 97201

Find articles by Neill, W. in: PubMed | Google Scholar

1Department of Medicine, University of Oregon Medical School, Portland, Oregon 97201

Find articles by Jensen, P. in: PubMed | Google Scholar

1Department of Medicine, University of Oregon Medical School, Portland, Oregon 97201

Find articles by Rich, G. in: PubMed | Google Scholar

1Department of Medicine, University of Oregon Medical School, Portland, Oregon 97201

Find articles by Werschkul, J. in: PubMed | Google Scholar

Published October 1, 1969 - More info

Published in Volume 48, Issue 10 on October 1, 1969
J Clin Invest. 1969;48(10):1862–1869. https://doi.org/10.1172/JCI106152.
© 1969 The American Society for Clinical Investigation
Published October 1, 1969 - Version history
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Abstract

Experiments were performed with trained conscious dogs with permanently implanted intravascular catheters. With the dogs in a basal resting state, the concentrations of lactate (L) and pyruvate (P) in arterial blood fluctuated widely from day to day, whereas their concentration ratio (L/P) remained relatively constant. By contrast, decrease in tissue O2 supply induced by severe chronic anemia increased the arterial blood L/P, specifically, with only random accompanying changes in the lactate or pyruvate concentrations themselves.

When systemic O2 consumption was increased acutely by muscular exercise, cardiac output increased, and the changes in blood L/P were small and not consistent between different dogs. But when O2 supply to the tissues was simultaneously limited by anemia, L/P increased during exercise, and the magnitude of the increase was proportional to the severity of the anemia. These results suggest that changes in blood L/P during exercise are related specifically to tissue O2 supply.

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