Measurement of thrombopoiesis in rabbits using ⁷⁵selenomethionine

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Abstract

Incorporation of 75selenomethionine (75SeM) has been used to study platelet production in rabbits. Radioactivity of platelets was low after the intravenous administration of 75SeM and rose to a maximum approximately 3 days after administration. Platelet radioactivity was independent of concurrent plasma levels. The life span of rabbit platelets, as estimated with this technique, was 4-5 days. In vivo reutilization of 75SeM previously incorporated into plasma proteins was not detected. In vitro incorporation of 75SeM by platelets in platelet-rich plasma was not demonstrated.

Authors

Bruce L. Evatt, Jack Levin