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Research Article Free access | 10.1172/JCI106032

Effects of secretin, pancreozymin, or gastrin on the response of the endocrine pancreas to administration of glucose or arginine in man

J. Dupre, J. D. Curtis, R. H. Unger, R. W. Waddell, and J. C. Beck

Division of Endocrinology and Metabolism, McGill University Clinic, Royal Victoria Hospital, Montreal, Quebec

Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, Texas 75216

Veterans Administration Hospital, Dallas, Texas 75216

Find articles by Dupre, J. in: PubMed | Google Scholar

Division of Endocrinology and Metabolism, McGill University Clinic, Royal Victoria Hospital, Montreal, Quebec

Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, Texas 75216

Veterans Administration Hospital, Dallas, Texas 75216

Find articles by Curtis, J. in: PubMed | Google Scholar

Division of Endocrinology and Metabolism, McGill University Clinic, Royal Victoria Hospital, Montreal, Quebec

Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, Texas 75216

Veterans Administration Hospital, Dallas, Texas 75216

Find articles by Unger, R. in: PubMed | Google Scholar

Division of Endocrinology and Metabolism, McGill University Clinic, Royal Victoria Hospital, Montreal, Quebec

Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, Texas 75216

Veterans Administration Hospital, Dallas, Texas 75216

Find articles by Waddell, R. in: PubMed | Google Scholar

Division of Endocrinology and Metabolism, McGill University Clinic, Royal Victoria Hospital, Montreal, Quebec

Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, Texas 75216

Veterans Administration Hospital, Dallas, Texas 75216

Find articles by Beck, J. in: PubMed | Google Scholar

Published April 1, 1969 - More info

Published in Volume 48, Issue 4 on April 1, 1969
J Clin Invest. 1969;48(4):745–757. https://doi.org/10.1172/JCI106032.
© 1969 The American Society for Clinical Investigation
Published April 1, 1969 - Version history
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Abstract

Intravenous administration of porcine secretin or pancreozymin or synthetic human gastrin II resulted in raised increments in serum immunoreactive insulin during intravenous infusion of glucose in normal man. Enhancement of serum immunoreactive insulin by each hormone was associated with accelerated disposal of glucose. In response to prolonged intravenous infusion of arginine with pancreozymin there was a maintained rise in immunoreactive insulin and glucagon-like immunoreactivity in the blood. These effects of pancreozymin and arginine were not reproduced with secretin and arginine, and may have been due to the stimulation of glucagon secretion together with insulin by pancreozymin.

Enteric infusion of hydrochloric acid, or stimulation of gastric acid secretion by betazole, presumed to cause release of endogenous secretin, led to enhancement of insulin secretion during intravenous infusion of glucose. Enteric infusion of arginine, presumed to cause release of endogenous pancreozymin, led to a rise in serum immunoreactive insulin not attributable to effects of circulating glucose and amino acids. It is concluded that secretin and pancreozymin released in response to physiological stimuli contribute to stimulation of the endocrine pancreas after ingestion of food.

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