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Research Article Free access | 10.1172/JCI106016

Liver and kidney metabolism during prolonged starvation

Oliver E. Owen, Philip Felig, Alfred P. Morgan, John Wahren, and George F. Cahill Jr.

Elliott P. Joslin Research Laboratory, Boston, Massachusetts 02215

Cardiovascular Unit, the Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115

Cardiovascular Unit, Department of Surgery, Harvard Medical School, Boston, Massachusetts 02115

Peter Bent Brigham Hospital, Boston, Massachusetts 02115

Joslin Diabetes Foundation, Inc., Boston, Massachusetts 02215

Find articles by Owen, O. in: JCI | PubMed | Google Scholar

Elliott P. Joslin Research Laboratory, Boston, Massachusetts 02215

Cardiovascular Unit, the Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115

Cardiovascular Unit, Department of Surgery, Harvard Medical School, Boston, Massachusetts 02115

Peter Bent Brigham Hospital, Boston, Massachusetts 02115

Joslin Diabetes Foundation, Inc., Boston, Massachusetts 02215

Find articles by Felig, P. in: JCI | PubMed | Google Scholar

Elliott P. Joslin Research Laboratory, Boston, Massachusetts 02215

Cardiovascular Unit, the Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115

Cardiovascular Unit, Department of Surgery, Harvard Medical School, Boston, Massachusetts 02115

Peter Bent Brigham Hospital, Boston, Massachusetts 02115

Joslin Diabetes Foundation, Inc., Boston, Massachusetts 02215

Find articles by Morgan, A. in: JCI | PubMed | Google Scholar

Elliott P. Joslin Research Laboratory, Boston, Massachusetts 02215

Cardiovascular Unit, the Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115

Cardiovascular Unit, Department of Surgery, Harvard Medical School, Boston, Massachusetts 02115

Peter Bent Brigham Hospital, Boston, Massachusetts 02115

Joslin Diabetes Foundation, Inc., Boston, Massachusetts 02215

Find articles by Wahren, J. in: JCI | PubMed | Google Scholar

Elliott P. Joslin Research Laboratory, Boston, Massachusetts 02215

Cardiovascular Unit, the Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115

Cardiovascular Unit, Department of Surgery, Harvard Medical School, Boston, Massachusetts 02115

Peter Bent Brigham Hospital, Boston, Massachusetts 02115

Joslin Diabetes Foundation, Inc., Boston, Massachusetts 02215

Find articles by Cahill, G. in: JCI | PubMed | Google Scholar

Published March 1, 1969 - More info

Published in Volume 48, Issue 3 on March 1, 1969
J Clin Invest. 1969;48(3):574–583. https://doi.org/10.1172/JCI106016.
© 1969 The American Society for Clinical Investigation
Published March 1, 1969 - Version history
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Abstract

This study quantifies the concentrations of circulating insulin, growth hormone, glucose, free fatty acids, glycerol, β-hydroxybutyrate, acetoacetate, and alpha amino nitrogen in 11 obese subjects during prolonged starvation. The sites and estimated rates of gluconeogenesis and ketogenesis after 5-6 wk of fasting were investigated in five of the subjects.

Blood glucose and insulin concentrations fell acutely during the 1st 3 days of fasting, and alpha amino nitrogen after 17 days. The concentration of free fatty acids, β-hydroxybutyrate, and acetoacetate did not reach a plateau until after 17 days.

Estimated glucose production at 5-6 wk of starvation is reduced to approximately 86 g/24 hr. Of this amount the liver contributes about one-half and the kidney the remainder. Approximately all of the lactate, pyruvate, glycerol, and amino acid carbons which are removed by liver and kidney are converted into glucose, as evidenced by substrate balances across these organs.

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