Advertisement

Research Article Free access | 10.1172/JCI105876

Studies of red cell stromal proteins in Tay-Sachs disease

John A. Balint and Emilios C. Kyriakides

1Department of Medicine (Gastroenterology), Albany Medical College, Albany, New York 12208

Find articles by Balint, J. in: PubMed | Google Scholar

1Department of Medicine (Gastroenterology), Albany Medical College, Albany, New York 12208

Find articles by Kyriakides, E. in: PubMed | Google Scholar

Published August 1, 1968 - More info

Published in Volume 47, Issue 8 on August 1, 1968
J Clin Invest. 1968;47(8):1858–1864. https://doi.org/10.1172/JCI105876.
© 1968 The American Society for Clinical Investigation
Published August 1, 1968 - Version history
View PDF
Abstract

Hemoglobin-free red blood cell ghosts of nine patients with Tay-Sachs disease and 14 normal control subjects have been analyzed for content of total protein, hexosamines, individual amino acids, and sialic acid. Red cell ghosts from Tay-Sachs' children have been shown to contain significantly increased amounts of protein, hexosamine, threonine, and serine, and probably sialic acid, each of which was increased by approximately 25% over control values. These observations suggest that the red cell membrane in patients with Tay-Sachs disease contains a significant excess of a glycoprotein or proteins, as compared with normal, and that the metabolic defect in this disease, therefore, affects glycoproteins as well as complex lipids.

Browse pages

Click on an image below to see the page. View PDF of the complete article

Version history
  • Version 1 (August 1, 1968): No description
Advertisement
Advertisement