Suppression of glycine-¹⁵N incorporation into urinary uric acid by adenine-8-¹³C in normal and gouty subjects

• Text
• PDF

Abstract

Adenine inhibited the de novo synthesis of purines in both normal and gouty man as shown by inhibition of the incorporation of glycine-15N into urinary uric acid without altering the incorporation of glycine-15N into urinary creatinine. The diminished purine synthesis did not result in a diminution in the 24 hr excretion of uric acid. This observation was explainable in part by the prompt conversion of adenine to uric acid. In addition to this direct conversion, adenine-8-13C provided a slow and prolonged contribution to urinary uric acid.

Authors

J. Edwin Seegmiller, James R. Klinenberg, John Miller, R. W. E. Watts