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Research Article Free access | 10.1172/JCI105720

The renal tubular handling of aldosterone and its acid-labile conjugate

Murphy T. Scurry, Leroy Shear, and Kevin G. Barry

Department of Metabolism, Walter Reed Army Institute of Research, Washington, D. C.

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Department of Metabolism, Walter Reed Army Institute of Research, Washington, D. C.

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Department of Metabolism, Walter Reed Army Institute of Research, Washington, D. C.

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Published February 1, 1968 - More info

Published in Volume 47, Issue 2 on February 1, 1968
J Clin Invest. 1968;47(2):242–248. https://doi.org/10.1172/JCI105720.
© 1968 The American Society for Clinical Investigation
Published February 1, 1968 - Version history
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Abstract

Stop-flow studies using infusions of aldosterone-3H or its 3H acid-labile conjugate were done on five rhesus monkeys. The aldosterone-3H urine-to-plasma (U/P) ratio decreased in the same distal urine samples as sodium. The 3H acid-labile conjugate U/P-to-inulin U/P ratio increased in the more proximal samples either with conjugate formed endogenously during aldosterone-3H infusions or with labeled conjugate infused alone. Aldosterone reabsorption occurred at a distal site in the renal tubule, and secretion of its acid-labile conjugate occurred at a proximal site.

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