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Comparative Effects of Insulin on Adipose Tissue Segments and Isolated Fat Cells of Rat and Man
F. Arnold Gries, Jürgen Steinke
F. Arnold Gries, Jürgen Steinke
Published September 1, 1967
Citation Information: J Clin Invest. 1967;46(9):1413-1421. https://doi.org/10.1172/JCI105633.
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Research Article

Comparative Effects of Insulin on Adipose Tissue Segments and Isolated Fat Cells of Rat and Man

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Abstract

In vitro metabolism of glucose-1-14C by adipose tissue into 14CO2 and total 14C lipids in rat and man was compared employing both adipose tissue segments and isolated fat cells prepared from the same donor. In the rat, the basal glucose metabolism and response to insulin decreased with increasing body weight for both adipose tissue segments and isolated cells. Regardless of age, the isolated cells exhibited a persistently higher metabolic activity. Of the parameters selected, conversion to CO2 was more pronounced than that to lipid.

Authors

F. Arnold Gries, Jürgen Steinke

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