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Research Article Free access | 10.1172/JCI105627

Total and Free Triiodothyronine in Human Serum

Janusz A. Nauman, Alicja Nauman, and Sidney C. Werner

Department of Medicine, Columbia University College of Physicians & Surgeons and The Presbyterian Hospital in the City of New York

‡

International postdoctoral research fellow (2-F05-TW-843-01), U. S. Public Health Service. Permanent address: II Department of Medicine, Postgraduate Medical School, Warsaw, Poland.

§

Permanent address: II Department of Medicine, Postgraduate Medical School, Warsaw, Poland.

ǁ

Address all reprint requests to Dr. Sidney C. Werner, Department of Medicine, 630 West 168th Street, New York, N. Y. 10032.

*

Submitted for publication March 3, 1967; accepted May 18, 1967.

This study was aided by grant AM 00008 (C17 and 18), National Institutes of Health, U. S. Public Health Service.

Find articles by Nauman, J. in: PubMed | Google Scholar

Department of Medicine, Columbia University College of Physicians & Surgeons and The Presbyterian Hospital in the City of New York

‡

International postdoctoral research fellow (2-F05-TW-843-01), U. S. Public Health Service. Permanent address: II Department of Medicine, Postgraduate Medical School, Warsaw, Poland.

§

Permanent address: II Department of Medicine, Postgraduate Medical School, Warsaw, Poland.

ǁ

Address all reprint requests to Dr. Sidney C. Werner, Department of Medicine, 630 West 168th Street, New York, N. Y. 10032.

*

Submitted for publication March 3, 1967; accepted May 18, 1967.

This study was aided by grant AM 00008 (C17 and 18), National Institutes of Health, U. S. Public Health Service.

Find articles by Nauman, A. in: PubMed | Google Scholar

Department of Medicine, Columbia University College of Physicians & Surgeons and The Presbyterian Hospital in the City of New York

‡

International postdoctoral research fellow (2-F05-TW-843-01), U. S. Public Health Service. Permanent address: II Department of Medicine, Postgraduate Medical School, Warsaw, Poland.

§

Permanent address: II Department of Medicine, Postgraduate Medical School, Warsaw, Poland.

ǁ

Address all reprint requests to Dr. Sidney C. Werner, Department of Medicine, 630 West 168th Street, New York, N. Y. 10032.

*

Submitted for publication March 3, 1967; accepted May 18, 1967.

This study was aided by grant AM 00008 (C17 and 18), National Institutes of Health, U. S. Public Health Service.

Find articles by Werner, S. in: PubMed | Google Scholar

Published August 1, 1967 - More info

Published in Volume 46, Issue 8 on August 1, 1967
J Clin Invest. 1967;46(8):1346–1355. https://doi.org/10.1172/JCI105627.
© 1967 The American Society for Clinical Investigation
Published August 1, 1967 - Version history
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Abstract

A reliable method has been developed for the determination of total serum T3, dialyzable fraction (DFT3), and absolute concentration of free T3 (AFT3). Total T3 values (mean ± SD) were: healthy euthyroid subjects, 0.33 ± 0.07 μg per 100 ml; hyperthyroid patients, 0.71 ± 0.1 μg per 100 ml; hypothyroid, 0.10 ± 0.03 μg per 100 ml. Values (mean ± SD) for DFT3 in these groups were 0.46 ± 0.14%, 0.78 ± 0.17%, and 0.16 ± 0.08%, respectively. Calculated values for AFT3 were: 1.51 ± 0.4 mμg per 100 ml, 5.00 ± 0.6 mμg per 100 ml and 0.24 ± 0.1 mμg per 100 ml, respectively. Dilution of serum before dialysis lowered estimated DFT3 values. Enrichment of serum with labeled T3 in the range examined did not affect DFT3. However, DFT3 was increased by addition of Merthiolate to serum in concentration 1: 10,000 due to displacement of T3 from thyroxine-binding globulin to albumin. The data suggest that triiodothyronine may play a considerably more important role in normal and pathological physiology, as evidenced by kinetic analysis using these data. A metabolic role for T3 equal to that of T4 is indicated.

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