Androstenedione and Its Conversion to Plasma Testosterone in Congenital Adrenal Hyperplasia

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Abstract

The plasma concentration, production rate, and conversion ratio of androstenedione and testosterone were studied in seven children with congenital adrenal hyperplasia (CAH) of the 21-hydroxylase type. Plasma androstenedione and testosterone measured by double isotope derivative assay and estimated blood production rates were manyfold increased in the untreated state, markedly suppressed with glucocorticoid, and increased after the administration of ACTH.

Authors

R. Horton, S. D. Frasier