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Research Article Free access | 10.1172/JCI105589

Androstenedione and Its Conversion to Plasma Testosterone in Congenital Adrenal Hyperplasia

R. Horton and S. D. Frasier

Department of Medicine, University of California, Los Angeles, School of Medicine, Los Angeles, Calif.

Department of Pediatrics, University of California, Los Angeles, School of Medicine, Los Angeles, Calif.

†

Holder of U. S. Public Health Service Career Development Award K3-AM-15,955.

Address requests for reprints to Dr. Richard Horton, Dept. of Medicine, School of Medicine, Center for the Health Sciences, Los Angeles, Calif. 90024.

*

Submitted for publication December 23, 1966; accepted March 10, 1967.

This work was supported by U. S. Public Health Service grant AM 10019 and grant P-404 from the American Cancer Society. Some of these studies were performed in the Clinical Research Center supported by U. S. Public Health Service grant FR 238.

Part of this work was presented at the Forty-eighth Meeting of the Endocrine Society, Chicago, June 1966.

Find articles by Horton, R. in: PubMed | Google Scholar

Department of Medicine, University of California, Los Angeles, School of Medicine, Los Angeles, Calif.

Department of Pediatrics, University of California, Los Angeles, School of Medicine, Los Angeles, Calif.

†

Holder of U. S. Public Health Service Career Development Award K3-AM-15,955.

Address requests for reprints to Dr. Richard Horton, Dept. of Medicine, School of Medicine, Center for the Health Sciences, Los Angeles, Calif. 90024.

*

Submitted for publication December 23, 1966; accepted March 10, 1967.

This work was supported by U. S. Public Health Service grant AM 10019 and grant P-404 from the American Cancer Society. Some of these studies were performed in the Clinical Research Center supported by U. S. Public Health Service grant FR 238.

Part of this work was presented at the Forty-eighth Meeting of the Endocrine Society, Chicago, June 1966.

Find articles by Frasier, S. in: PubMed | Google Scholar

Published June 1, 1967 - More info

Published in Volume 46, Issue 6 on June 1, 1967
J Clin Invest. 1967;46(6):1003–1009. https://doi.org/10.1172/JCI105589.
© 1967 The American Society for Clinical Investigation
Published June 1, 1967 - Version history
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Abstract

The plasma concentration, production rate, and conversion ratio of androstenedione and testosterone were studied in seven children with congenital adrenal hyperplasia (CAH) of the 21-hydroxylase type. Plasma androstenedione and testosterone measured by double isotope derivative assay and estimated blood production rates were manyfold increased in the untreated state, markedly suppressed with glucocorticoid, and increased after the administration of ACTH.

The metabolic clearance rate when corrected for body size and the conversion ratio of androstenedione to testosterone were similar to previously determined values in normal adults. Consideration of the androgen concentrations and conversion ratios indicates that in children with CAH, 76% of the plasma testosterone in prepubertal females and 36% in males are derived from peripheral conversion of blood androstenedione. The calculated amount of testosterone unaccounted for by peripheral conversion is similar to normal prepubertal values. This approach indicates that virilization in these children results from increased levels of testosterone but that the major source in CAH of this potent androgen is androstenedione secreted by the adrenal cortex.

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