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Research Article Free access | 10.1172/JCI105570

The Role of “Leakage” of Tubular Fluid in Anuria Due to Mercury Poisoning

Norman Bank, Bertrand F. Mutz, and Hagop S. Aynedjian

Department of Medicine, New York University School of Medicine, New York, N. Y.

†

Career Scientist of the Health Research Council of New York City. Address requests for reprints to Dr. Norman Bank, Dept. of Medicine, New York University School of Medicine, 550 First Ave., New York, N. Y.

*

Submitted for publication July 12, 1966; accepted January 4, 1967.

This work was supported by grants from the National Heart Institute (HE-05770), the American Heart Association, and the Life Insurance Medical Research Fund.

Find articles by Bank, N. in: PubMed | Google Scholar

Department of Medicine, New York University School of Medicine, New York, N. Y.

†

Career Scientist of the Health Research Council of New York City. Address requests for reprints to Dr. Norman Bank, Dept. of Medicine, New York University School of Medicine, 550 First Ave., New York, N. Y.

*

Submitted for publication July 12, 1966; accepted January 4, 1967.

This work was supported by grants from the National Heart Institute (HE-05770), the American Heart Association, and the Life Insurance Medical Research Fund.

Find articles by Mutz, B. in: PubMed | Google Scholar

Department of Medicine, New York University School of Medicine, New York, N. Y.

†

Career Scientist of the Health Research Council of New York City. Address requests for reprints to Dr. Norman Bank, Dept. of Medicine, New York University School of Medicine, 550 First Ave., New York, N. Y.

*

Submitted for publication July 12, 1966; accepted January 4, 1967.

This work was supported by grants from the National Heart Institute (HE-05770), the American Heart Association, and the Life Insurance Medical Research Fund.

Find articles by Aynedjian, H. in: PubMed | Google Scholar

Published May 1, 1967 - More info

Published in Volume 46, Issue 5 on May 1, 1967
J Clin Invest. 1967;46(5):695–704. https://doi.org/10.1172/JCI105570.
© 1967 The American Society for Clinical Investigation
Published May 1, 1967 - Version history
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Abstract

The role of “leakage” of tubular fluid in anuria produced by mercury poisoning was studied in rats by micropuncture techniques. After an initial brisk diuresis, almost all animals were completely anuric 24 hours after HgCl2 injection. Lissamine green injected intravenously in the early stage of anuria appeared in the beginning of the proximal tubule, but the color became progressively lighter as the dye traversed the proximal convolutions. The dye was barely visible in the terminal segments of the proximal tubule; it did not appear at all in the distal tubules. These observations suggest that the proximal epithelium had become abnormally permeable to Lissamine green.

Tubular fluid to plasma inulin (TF/PIn) ratios and inulin clearance were measured in individual nephrons at three sites: early proximal tubule, late proximal tubule, and distal tubule. It was found that TF/PIn ratios were abnormally low in the late proximal and distal tubules. Inulin clearance was normal at the beginning of the proximal tubule but fell by more than 60% by the late proximal convolutions. Thus, the proximal tubule had also become permeable to inulin.

We conclude from these observations that anuria in mercury poisoning can occur in the presence of a normal glomerular filtration rate. The absence of urine flow appears to be due to complete absorption of the filtrate through an excessively permeable tubular epithelium. The driving force affecting this fluid absorption is probably the colloid oncotic pressure of the peritubular capillary blood.

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