Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Alerts
  • Advertising
  • Job board
  • Subscribe
  • Contact
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Author's Takes
  • Reviews
    • View all reviews ...
    • Aging (Upcoming)
    • Next-Generation Sequencing in Medicine (Jun 2022)
    • New Therapeutic Targets in Cardiovascular Diseases (Mar 2022)
    • Immunometabolism (Jan 2022)
    • Circadian Rhythm (Oct 2021)
    • Gut-Brain Axis (Jul 2021)
    • Tumor Microenvironment (Mar 2021)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Commentaries
    • Concise Communication
    • Editorials
    • Viewpoint
    • Top read articles
  • Clinical Medicine
  • JCI This Month
    • Current issue
    • Past issues

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Author's Takes
  • In-Press Preview
  • Commentaries
  • Concise Communication
  • Editorials
  • Viewpoint
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Alerts
  • Advertising
  • Job board
  • Subscribe
  • Contact
Top
  • View PDF
  • Download citation information
  • Send a comment
  • Share this article
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal
  • Top
  • Abstract
  • Version history
  • Article usage
  • Citations to this article

Advertisement

Research Article Free access | 10.1172/JCI105563

Studies on Antibody to Intrinsic Factor

Stanley G. Schade, Johannes Abels, Robert F. Schilling, Patricia Feick, and Mary Muckerheide

Department of Medicine, University of Wisconsin Medical School, Madison, Wis.

†

Postdoctoral research fellow.

‡

Research fellow of the Netherlands Organization for the Advancement of Pure Research (ZWO).

§

Address requests for reprints to Dr. Robert F. Schilling, Dept. of Medicine, University of Wisconsin, 1300 University Ave., Madison, Wis. 53706.

*

Submitted for publication September 20, 1966; accepted December 22, 1966.

Supported by research and training grants from the National Institutes of Health.

Find articles by Schade, S. in: JCI | PubMed | Google Scholar

Department of Medicine, University of Wisconsin Medical School, Madison, Wis.

†

Postdoctoral research fellow.

‡

Research fellow of the Netherlands Organization for the Advancement of Pure Research (ZWO).

§

Address requests for reprints to Dr. Robert F. Schilling, Dept. of Medicine, University of Wisconsin, 1300 University Ave., Madison, Wis. 53706.

*

Submitted for publication September 20, 1966; accepted December 22, 1966.

Supported by research and training grants from the National Institutes of Health.

Find articles by Abels, J. in: JCI | PubMed | Google Scholar

Department of Medicine, University of Wisconsin Medical School, Madison, Wis.

†

Postdoctoral research fellow.

‡

Research fellow of the Netherlands Organization for the Advancement of Pure Research (ZWO).

§

Address requests for reprints to Dr. Robert F. Schilling, Dept. of Medicine, University of Wisconsin, 1300 University Ave., Madison, Wis. 53706.

*

Submitted for publication September 20, 1966; accepted December 22, 1966.

Supported by research and training grants from the National Institutes of Health.

Find articles by Schilling, R. in: JCI | PubMed | Google Scholar

Department of Medicine, University of Wisconsin Medical School, Madison, Wis.

†

Postdoctoral research fellow.

‡

Research fellow of the Netherlands Organization for the Advancement of Pure Research (ZWO).

§

Address requests for reprints to Dr. Robert F. Schilling, Dept. of Medicine, University of Wisconsin, 1300 University Ave., Madison, Wis. 53706.

*

Submitted for publication September 20, 1966; accepted December 22, 1966.

Supported by research and training grants from the National Institutes of Health.

Find articles by Feick, P. in: JCI | PubMed | Google Scholar

Department of Medicine, University of Wisconsin Medical School, Madison, Wis.

†

Postdoctoral research fellow.

‡

Research fellow of the Netherlands Organization for the Advancement of Pure Research (ZWO).

§

Address requests for reprints to Dr. Robert F. Schilling, Dept. of Medicine, University of Wisconsin, 1300 University Ave., Madison, Wis. 53706.

*

Submitted for publication September 20, 1966; accepted December 22, 1966.

Supported by research and training grants from the National Institutes of Health.

Find articles by Muckerheide, M. in: JCI | PubMed | Google Scholar

Published April 1, 1967 - More info

Published in Volume 46, Issue 4 on April 1, 1967
J Clin Invest. 1967;46(4):615–620. https://doi.org/10.1172/JCI105563.
© 1967 The American Society for Clinical Investigation
Published April 1, 1967 - Version history
View PDF
Abstract

Sera from a group of 79 patients with pernicious anemia were studied for the presence of antibody to intrinsic factor. Two general types of antibody activity were found, and it was possible to distinguish three groups of pernicious anemia sera on the basis of their content of these types.

Type I antibody blocks the binding of radioactive vitamin B12 to intrinsic factor when added to intrinsic factor before the B12; it is not detected on intrinsic factor when added after B12. This antibody blocks intrinsic factor-mediated B12 absorption in vivo when mixed in the sequence intrinsic factor + antibody I + B12, but not when mixed in the sequence intrinsic factor + B12 + antibody I.

Type II antibody reacts with intrinsic factor when B12 is attached. This antibody prevents the absorption of B12 from intrinsic factor in pernicious anemia patients when mixed in the sequence intrinsic factor + B12 + antibody II, and is thereby distinguished from antibody I.

Browse pages

Click on an image below to see the page. View PDF of the complete article

icon of scanned page 615
page 615
icon of scanned page 616
page 616
icon of scanned page 617
page 617
icon of scanned page 618
page 618
icon of scanned page 619
page 619
icon of scanned page 620
page 620
Version history
  • Version 1 (April 1, 1967): No description

Article tools

  • View PDF
  • Download citation information
  • Send a comment
  • Share this article
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal

Metrics

  • Article usage
  • Citations to this article

Go to

  • Top
  • Abstract
  • Version history
Advertisement
Advertisement

Copyright © 2022 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts