Evidence for In Vivo Breakdown of β_1C-Globulin in Hypocomplementemic Glomerulonephritis

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Abstract

Evidence has been obtained for the presence in vivo of alpha2D-globulin, a breakdown product of serum β1C-globulin, in patients with acute and persistent hypocomplementemic glomerulonephritis. The protein has been identified by immunoelectrophoretic analysis, and the amounts present have been determined by direct measurement of specific antigenic determinants present on alpha2D. β1A-Globulin, another breakdown product of β1C-globulin, may also be present in vivo in severely hypocomplementemic patients, but its levels are much lower than those of alpha2D-globulin.

Authors

Clark D. West, Sara Winter, Judith Forristal, Janice M. McConville, Neil C. Davis