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Research Article Free access | 10.1172/JCI105552
Division of Gastroenterology, Department of Medicine, Cornell University Medical College, New York, N. Y.
†Current address: University of Texas South Texas Medical School, San Antonio, Texas.
‡Address requests for reprints to Dr. Marvin H. Sleisenger, New York Hospital, 525 E. 68th St., New York, N. Y. 10021.
*Submitted for publication September 29, 1966; accepted December 8, 1966.
Supported by grants from the New York City Health Research Council (1-288 and U-1573) and the John A. Hartford Foundation.
Find articles by Weser, E. in: JCI | PubMed | Google Scholar
Division of Gastroenterology, Department of Medicine, Cornell University Medical College, New York, N. Y.
†Current address: University of Texas South Texas Medical School, San Antonio, Texas.
‡Address requests for reprints to Dr. Marvin H. Sleisenger, New York Hospital, 525 E. 68th St., New York, N. Y. 10021.
*Submitted for publication September 29, 1966; accepted December 8, 1966.
Supported by grants from the New York City Health Research Council (1-288 and U-1573) and the John A. Hartford Foundation.
Find articles by Sleisenger, M. in: JCI | PubMed | Google Scholar
Division of Gastroenterology, Department of Medicine, Cornell University Medical College, New York, N. Y.
†Current address: University of Texas South Texas Medical School, San Antonio, Texas.
‡Address requests for reprints to Dr. Marvin H. Sleisenger, New York Hospital, 525 E. 68th St., New York, N. Y. 10021.
*Submitted for publication September 29, 1966; accepted December 8, 1966.
Supported by grants from the New York City Health Research Council (1-288 and U-1573) and the John A. Hartford Foundation.
Find articles by Dickstein, M. in: JCI | PubMed | Google Scholar
Division of Gastroenterology, Department of Medicine, Cornell University Medical College, New York, N. Y.
†Current address: University of Texas South Texas Medical School, San Antonio, Texas.
‡Address requests for reprints to Dr. Marvin H. Sleisenger, New York Hospital, 525 E. 68th St., New York, N. Y. 10021.
*Submitted for publication September 29, 1966; accepted December 8, 1966.
Supported by grants from the New York City Health Research Council (1-288 and U-1573) and the John A. Hartford Foundation.
Find articles by Bartley, F. in: JCI | PubMed | Google Scholar
Published April 1, 1967 - More info
The metabolism of circulating disaccharides was studied in adult humans and rats. After iv infusions of 10 g of either lactose, sucrose, or maltose in four adults, no rise in blood glucose was noted. A mean of 8.7±1.89 g of the lactose and 6.3±1.39 g of the sucrose was excreted in the 24-hour urine sample. Only 0.11±0.03 g of the infused maltose was recovered in the urine, suggesting that the maltose was metabolized.
After injection of 14C-labeled lactose and sucrose in rats, 6.2±2.7 and 7.6±2.4%, respectively, was oxidized to 14CO2 in 24 hours; 62.1±13.5 and 68.4±10.8% of the respective disaccharides was excreted into the urine. Conversely, after injection of 14C-labeled maltose 54.6±7.0% was oxidized to 14CO2 and 4.8±3.9% excreted in the urine. The per cent of maltose oxidized to CO2 was similar to that of glucose.
In addition to small intestinal mucosa, homogenates of rat kidney, brain, and liver as well as serum were found to have measurable maltase activities. The role of these tissue maltases in the metabolism of circulating maltose and maltosyloligosaccharides is discussed.