Collagen Degradation and the Response to Parathyroid Extract in the Intact Rhesus Monkey

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Abstract

Proline-14C was administered to five adult rhesus monkeys, and the degradation of collagen was followed by the excretion of hydroxyproline-14C. The results suggested the presence of at least three separate pools of collagen with half-lives of 1 to 2, 2 to 3, and 50 to 70 days. The monkeys were killed after 44 days; at that time the specific activity of the hydroxyproline-14C in urine was found to be four to five times that of the hydroxyproline in soluble collagen and 81 to 93% that of hydroxyproline in insoluble collagen. The relationships between urinary hydroxyproline and the degradation of collagen were similar to those previously demonstrated in rats.

Authors

Louis V. Avioli, Darwin J. Prockop